Cosmelan

cosmelan ® : what is it and what does it consist in? cosmelan ® is a depigmenting method that fully removes spots of melanic origin and prevents their reappearance, achieving a short-term outcome while keeping the hyperpigmentation under control for a long-lasting outcome. antiaging action 4 cosmesome ® A flexible, encapsulated complex containing two active ingredients with antioxidant properties: apigeninandphloretin . Its three-dimensional structure provides stability to the active ingredients. Auto-regulating mechanism for the overproduction of melanin. X 3 autophagy marker Reduction of the gene expression of enzymes that activate melanogenesis. Increase in collagen and elastin synthesis. Reduction of metalloprotei- nases (MMPs), enzymes that degrade collagen. Encapsulated complex Epigenetics 3 Autophagy 2 DEPIGMENTATION ACTION Total melanin test in melanocyte culture stimulated with L-Tyrosine and treated with cosmelan ® . in-vitro results - 90 % ex-vivo results 1 Control cosmelan ® melanin synthesis EFFICACY OF cosmesome ® We have proven the efficacy of the depigmentation action of the complex encapsulated by a conduction system made up of apigenin and phloretin. 0 -47 % % melanin synthesis 5 Control 10 20 30 40 50 60 70 80 90 100 cosmesome ® in-vitro results ATG5, ATG7, LC3 DCT, MITF y TYRP1 TIMP1, which inhibits MMPs less melanin