Cosmelan

Patent that endorses its innovation Own molecular design. Its 3D conformational and molecular structure offers high safety and specificity in inhibiting the enzyme tyrosinase’s activity. melaphenone ® EFFICACY OF melaphenone ® Its efficacy in inhibiting enzyme tyrosinase is proven by regulating melanin synthesis. 0 -56 % % tyrosinase activity 6 Control 10 20 30 40 50 60 70 80 90 100 Melanocyte culture stimulated and treated with melaphenone ® . melaphenone ® In real-time 3D microscopy we can see that glycation causes cell damage involving the typical morphological changes of cell death (control). We have demonstrated an anti-glycation action in cells treated with melaphenone ® , as cell activity and its integrity are maintained. As a result, the active ingredient protects against the damage induced by glycation. ANTI-GLYCATION ACTION 8 melaphenone ® control in-vitro results They are subjected to oxidative stress in a test conducted on fibroblasts cultures that are applied by a fluorogenic probe. control + oxidative stress In the control subject to oxidative stress, we observe an increase in fluorescence (mainly in the nucleus), which is related to cell damage. melaphenone ® + oxidative stress In the fibroblasts culture subject to oxidative stress and treated with melaphenone ® , we observe a lower signal, similar to the initial state, which evidences the protective effect of melaphenone ® and its antioxidant capacity. OXIDATIVE ANTI-STRESS ACTION 7 fibroblast - oxidative stress DEPIGMENTATION ACTION