Dermamelan

mesopeel melanostop tran 3 x 50 mL 20% azelaic + 10% resorcinol + 6% phytic + 3% tranexamic acid Depigmenting peel that re- moves the accumulated melanin and regulates melanocyte activi- ty. Its formula provides a perfect balance between efficacy and tolerance. melan tran3x concentrate & gel cream 30 mL / 50 mL Home depigmenting pro- gramme with synergistic action formulae that act daily and progressively on hyperpigmen- tations, reducing dark spots. With tranexamic acid. mesopeel melanoplus 5 x 5 mL 20% trichloroacetic acid + 4% kojic acid + 1% ferulic acid + tazarotene Depigmenting peel for focal use to treat resistant hyperpigmen- tations. Self-neutralising. For medical use only. c.prof 210 depigmentation solution 5 x 5 mL Vitamin C + idebenone + NAG (n-acetyl glucosamine) + tranexamic acid Transepidermal solution that regulates melanin production and removes the melanin responsible for visible pigmen- tation. It contains antioxidant agents that regulate melanin overproduction. dermamelan ® and laser 8 In medium and high photo- types, the efficacy of laser is less precise and the risk of PIH is higher. In these profiles, dermamelan method is prefer- ably recommended due to its profile of tolerance, efficacy and lower risk of relapses. Furthermore, in light photo- types the combination of laser treatment with dermamelan enhances treatment success, correcting and controlling melanin overproduction, offering a more intense and longer-lasting solution. pH 1.3 pH<1 Other complementary depigmenting solutions + Professional medical products Home products SYNERGISTIC ACTIVITY OF [SYN]pigmentarget ® Synergy is demonstrated by comparing inhibition of tyrosinase activity of the actives separately vs. the actives together. TOTAL MELANIN Inhibition of melanin formed in a culture of treated melanocytes vs. control culture. Inhibits the dendricity of melanocytes cultured with α -MSH . Inhibition of the DCT enzyme in melanocytes stimulated with ET-1 . Inhibition of the PG-2 -producing enzyme Improved TIMP3 expression that inhibits MMP that degra- de collagen IV. 0 0 0 dermamelan ® In-vitro efficacy studies Assessment of the efficacy of dermamelan ® in the activity of the different intercellular pathways HORMONAL VASCULAR INFLAMMATION TISSUE STRUCTURES - 78 % - 35 % + 60 % Culture of melanocytes stimulated with L-tyrosine (1) . Melanocytes stimulated with L-tyrosine (9) . Study in vitro (microscopy) (3) culture of melanocytes stimulated with IBMX, an activator of the α -MSH pathway. Study in vitro (qPCR) (4) culture of melanocytes stimulated with ET-1 and treated with derma- melan ® Study in vitro (qPCR) (5) culture of fibroblasts stimulated with IL-1 and treated with dermamelan ® Study in vitro (qPCR) (6) culture of fibroblasts treated with dermamelan ® -22% -54% -56 % -89 % x 2.5 % of activity of tyrosinase % of activity of tyrosinase % melanin synthesis Control Control Control Addition of active ingredients 20 10 10 40 20 20 60 30 30 80 40 40 100 50 50 120 60 60 140 70 70 160 80 80 180 90 90 100 100 EFFICACY OF melaphenone ® It demonstrates the effectiveness of its inhibitory action of the enzyme tyrosinase achieve a regulation of melanin synthesis. Culture of melanocytes stimulated with melaphenone ®(2) . [SYN]pigmentarget ® melaphenone ® dermamelan ® control culture culture treated with dermamelan ® method active ingredients