Dermamelan

Big data Artificial intelligence Computational design dermamelan ® dermamelan ® is the depigmentation method that provides an intensive corrective action on skin hyperpigmentations while regulating melanin overproduction, controlling reappearance of new spots in the long term. A cutting-edge formula dermamelan ® method combines the experience of mesoestetic ® in the field of hyperpigmentation with the latest scientific research and the application of new technologies for its development: [SYN]pigmentarget ® Unique combination of three selected active ingredients formulated at optimum concentrations, for a high-synergism therapeutic response in the interaction with key pigmentation targets. (1) Two patents supporting its innovation Transepidermal vehiculation systems melaphenone ® Own molecular design. Its molecular structure and 3D confor- mation provide a high specificity and safety in the inhibition of the activity of tyrosinase enzyme. (2) new PATENTS mesoestetic ® 2 Multilamellar nanovesicles with targeted action Carries and releases active ingredients selectively and improves their stability. Iontophoresis Technology that allows the formation of microchannels to improve permeability and facilitate that the active ingredient reaches its site of action. Actions & Mechanisms The latest medical-scientific developments in the field of hyperpigmentation have enabled us to identify new molecular targets responsible for the disease. dermamelan ® has been formulated specifically to act effectively and synergistically on the main key targets in the skin hyperpigmentation process. Its dual corrective and regulating action achieves a unique integral treatment to remove the existing spots and prevent their reappearance. Protective action against destruc- turing of the dermal-epidermal barrier preventing the formation of dermal melasma . (6) Controls the different pigmenta- tion mechanisms, reducing melanin synthesis . Inhibition of melanocyte-ke- ratinocyte transfer. (1, 2) Accelerating the cell renewal process, remov- ing the melanin deposits built up in the stratum corneum. (7) It inhibits the main molecular mechanisms triggering overstimulation of the melanocyte associated with the inflammatory, vascular and hormonal component characteristic of the most resistant hyperpigmentations. (3, 4, 5) REGULATING ACTION TISSUE STRUCTURES INTERCELLULAR ACTION INTRACELLULAR ACTION HORMONAL VASCULAR PIGMENTATION VISBLE SPOT INFLAMMATION CORRECTIVE ACTION EPIDERMIS DERMIS keratinocyte mast cell PG-2 α -MSH ET-1