Global Antiaging Solutions Catalougue EN

KFDGLA0010/2211 mesoestetic Pharma Group, s.l. C/ Tecnologia, 25 08840 - Viladecans (Barcelona) Tel. +34 93 325 20 30 www.mesoestetic.com made in Spain Formulas designed to treat more precisely each of the manifestations of aging. Versatility in antiaging treatments to act globally on all signs of skin aging. Antiaging efficacy backed by in vitro studies and visible in vivo results Exclusive combinations of active ingredients aimed at maximising antiaging results in skin, based on the indication. GLOBAL ANTIAGING SOLUTIONS 1. qPCR teston fibroblastswithRetinol+Bakuchiol+Prorenew.BiotechnologyUnit.mesoesteticPharmaGroupS.L.2022. 2. Woundhealing teston fibroblastswithRetinol+Bakuchiol+Prorenew.BiotechnologyUnit.mesoestetic PharmaGroupS.L.2022. 3. MESO_0822studytoassessthesafety,efficacyandtoleranceofthecosmeticproductskinretin0.3%.BiomedicalEngineeringUnit.mesoesteticPharmaGroupS.L.2022. 4. Studyon immunodetection of Cytokeratin 14, Ki-67, Filaggrin and Collagen IV in full thickness reconstructed human skin models. Biotechnology Unit. Biomedical Engineering Unit. mesoestetic Pharma Group S.L. 2022. 5. Study on the efficacy of ferulic acid as a cell protector against UVA radiation. Biotechnology Unit. mesoestetic Pharma Group S.L. 2017. 6. Study on the antioxidant capacity of Ascorbic Acid against the radical DPPH. Biotechnology Unit. mesoestetic Pharma Group,S.L.2017. 7. Studyon theefficacyofProtech-cellcomplexasanantioxidantandcellprotector.BiotechnologyUnit. mesoesteticPharmaGroup,S.L.2017. 8. BiotechnologyUnit.Studyon the inductioncapacityofAscorbyl Glucoside in increasing collagen synthesis. mesoestetic Pharma Group, S.L. 2015. 9. In vitro study on epidermal cells (fibroblasts) demonstrating the protective effect of Idebenone when inhibiting the synthesis of the MMP-1 enzyme, responsible for collagen degradation. Biotechnology Unit. mesoestetic Pharma Group S.L. 10. In vitro study conducted on cell culture in the presence of oxidising agents (DPPH). An inhibition of the oxidative activity of DPPH is observed in the culture treated with Chroton lechleri when compared to the untreated culture. Biotechnology Unit. mesoestetic Pharma Group S.L. 11. Subjective self-assessment test performed after 28 days of using with pollution defense ampoules. Medical Affairs. mesoestetic Pharma Group S.L. 2018. 12. In-vivo study employing a cutometer after 28 days of using with antiaging flash ampoules. Medical Affairs. mesoestetic Pharma GroupS.L.2018. 13. Subjectiveself-assessment testperformedafter28daysofusingwithantiaging flashampoules.MedicalAffairs.mesoesteticPharmaGroupS.L.2018. 14. Invitrostudyusingspectrophotometry tomeasure the cellular protection capacity of melatonin against the oxidative stress produced by UVA radiation. Biotechnology Unit. mesoestetic Pharma Group. 2017 15. In-vivo study employing a cutometer after 28 days of using with melatonin ampoules. Medical Affairs. mesoestetic Pharma Group S.L. 2018. 16. Subjective self-assessment test performed after 28 days of using with melatonin ampoules. Medical Affairs. mesoestetic Pharma Group S.L. 2018. 17. In-vivo study employing a cutometer after 28 days of using with proteoglycans ampoules. Medical Affairs. mesoestetic Pharma Group S.L. 2018. 18. Subjective self-assessment test performed after 28 days of using with proteoglycansampoules.MedicalAffairs.mesoesteticPharmaGroupS.L. 2018. 19. E.Michishita,R.A.McCord,E.Berber,M.Kioi,H.Padilla-Nash,M.Damian,P.Cheun,R.Kusumoto,T.L.A.Kawahara,J.CarlBarrett,H.Y.Chang,V. A.Bohr,T.Ried,O.Gozani,andK.F.Chua.SIRT6 isahistoneH3 lysine9 deacetylase thatmodulates telomericchromatin.Nature.2008March27;452(7186):492–496. 20. Shin-HaeLee,Ji-HyeonLee,Hye-YeonLee,andKyung-Jin Min.BMBRep.Sirtuinsignaling incellularsenescenceandaging.2019 Jan;52(1):24–34. 21. N.Yuan,X.Zhang,N.Sengupta,W.S.Lane2,andE.Seto.sIRT1 regulates the functionof theNijmegenbreakagesyndromeprotein.Mol Cell. 2007July 6; 27(1): 149–162. 22. W. Fan and J. Luo. SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol Cell. 2010; 39: 247–258.