AGE ELEMENT Personalised Anti-aging Science

INCREASES CELL LONGEVITY Control Photooxidative stress (UVB) + Shikimic acid 50 Mm Aging and exposure to some external factors cause a shortening of telomeres, reducing genetic material protection. Autophagy process inside the cell: Cells treated with active ingredients of the [meso] epigen system TM complex have a greater telomere length than untreated cells irradiated with UV. The graph shows how shikimic acid increases gene expression of VMP1, increasing and activating it to promote the autophagy pathway. Photooxidative stress (UVB) Photooxidative stress ( UVB) + Shikimic acid 50 Mm + SIRT1 inhibitor The protective effect of shikimic acid on senescence is dependent on SIRT1: epigenetic technology. (7) Senescent cells Senescent cells Senescent cells PROTECTS DNA [meso]epigen system TM avoids the te- lomere shortening caused by oxidative stress. (8,9) IMPROVES CELL PERFORMANCE It stimulates proteins such as VMP1 which are important in the cell autophagy process, whereby toxic materials that can damage cells are removed. (10) 1.0 1.5 2.0 2.5 no UVB control UVB control UVB [meso]epigen system™ Relative telomere length 3.0 0.0 C 10 25 50 Shikimic acid (mM) 1.0 2.0 3.0 Gene expression of VMP1 mRNA levels antiaging professional solutions EFFICACY STUDIES: [meso]epigen system TM ACTIVATION OF THE YOUTH PROTEIN: SIRT1 Sirtuin 1 prolongs cell longevity, improves the response to oxidative stress and is involved in DNA protection processes through an epigenetic mechanism: chemical modification of histones. (3) Telomere length telomere chromosome damaged components degradation and recycling of damaged components Senescent cells: blue staining.