AGE ELEMENT Personalised Anti-aging Science

KPPAGE0003/2012 mesoestetic Pharma Group, s.l. C/ Tecnologia, 25 08840 - Viladecans (Barcelona) Tel. +34 93 325 20 30 www.mesoestetic.com made in Spain Formulas with the patented technology meso[epigen] system™ to combat aging from its origin. Latest generation professional antiaging system inspired by the most advanced medical-cosmetic technology. 100% customised protocol from a unique diagnostic system: age element diagnosis system™ An integral antiaging solution with all essential phases and customised sessions, building unique experiences in each session. antiaging professional solutions 1. Rando, T. A. and Chang, H. Y. Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell. 2012; 148 (1-2): 46. 2. Masood A. Shammas. Telomeres, lifestyle, cancer, and aging. Curr Opin Clin Nutr Metab Care. 2011 Jan; 14(1): 28–34. 3. E.Michishita, R. A. McCord, E. Berber, M. Kioi, H. Padilla- Nash, M. Damian, P. Cheun, R. Kusumoto, T. L. A. Kawahara, J. Carl Barrett, H. Y. Chang, V. A. Bohr, T. Ried, O. Gozani, and K. F.Chua. SIRT6 is a histoneH3 lysine9deacetylase thatmodulates telomericchromatin.Nature.2008March27;452(7186):492–496. 4. Maslinicacid:Thesecretof longevity,E.Grau,Cosmetic Industry,002; 2017. 5. Y.-h.chen,L.huang,Z.-h.wen, C.zhang,C.-h. liang,S.-t. lai,L.-z. luo,Y.-y.wang,G.-h.Wang.Skinwhiteningcapabilityofshikimicacidpathwaycompounds.EurRevMedPharmacolSci.2016;21214-12200: 6. E.Schadich,J.HlaváI,T.Volná,L.Varanasi,M.Hajdúch, and P. DDubák. Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-A Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes. Hindawi Publishing Corporation, BioMed Research International. 2016, 2173275, 6 pages. 7. Shin-Hae Lee, Ji-Hyeon Lee, Hye-Yeon Lee, and Kyung-Jin Min.BMB Rep. Sirtuin signaling in cellular senescence and aging. 2019 Jan; 52(1): 24–34. 8. N. Yuan, X. Zhang, N. Sengupta, W. S. Lane2, and E. Seto. sIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell. 2007July 6; 27(1): 149–162. 9. W. Fan and J. Luo. SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol Cell. 2010; 39: 247–258. 10. In Hye Lee, L. Cao, R. Mostoslavsky, D. B. Lombard, J. Liu, N. E. Bruns, M. Tsokos, Fr. W. Alt, and T. Finkel.A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy .PNAS. 2008; 105(9) 3374–3379.