dermamelan@ intimate-EN

KFMFIL0061/2210 mesoestetic Pharma Group, s.l. C/ Tecnologia, 25 08840 - Viladecans (Barcelona) Tel. +34 93 325 20 30 www.mesoestetic.com made in Spain intimate medical solutions Solutions for women’s intimate treatment that provide tangible results and a high degree of satisfaction in our patients. Solutions developed by specialist gynaecologists for function and aesthetic regeneration of women’s intimate area, providing comfort and improving quality of life . High clinical efficacy results evidenced by parameters of vaginal health and studies in vivo . Efficacy demonstrated in studies performed by external organisms in women’s intimate rejuvenation. 1. Gandhi J, Chen A, Dagur G, Suh Y; Smith N, Cali B, Ali Khan S. Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management. Am J Obstet Gynecol. 2016;215(6):704-711. 2. Gloria Bachmann, MD, Richard J Santen, MD. Clinical manifestations and diagnosis of genitourinary syndrome of menopause (vulvovaginal atrophy). Uptodate: Robert L Barbieri, MD. [Internet]; 2019. [Reviewed on 11 February 2020]. 3. Shugusheva L., Gvasalia B., Tcakhilova S., Sarakhova D. Efficacy of injectable hyaluronic acid for the treatment of dyspareunia. Journal of Sexual Medicine 2016 13:5 SUPPL. 2 (S121-). 2. Keen MA. Hyaluronic acid in dermatology. Skinmed 2017;15:441-448. 4. Gaspar A, Palikov K, Luis Shotze Luis G. An open-label uncontrolled single centre study for the evaluation of the performance characteristics (efficacy and safety) of mesofiller® sensitive (20 mg/ml) for female intimate area hydration and atrophy of the vagina. 5. Gaspar A, Tsvetkov D, Luis Shotze Luis G. An open-label uncontrolled single centre study for the evaluation of the performance characteristics (efficacy and safety) of mesofiller® sensitive plus (25 mg/ml) female intimate area augmentation of labia majora. 6. Simmler, C., Pauli, G. F., & Chen, S.-N. (2013). Phytochemistry and biological properties of glabridin, 90, 160–184. doi:10.1016/j.fitote.2013.07.003. 7. YOKOTA, T., NISHIO, H., KUBOTA, Y., & MIZOGUCHI, M. (1998). The Inhibitory Effect of Glabridin from Licorice Extracts on Melanogenesis and Inflammation. Pigment Cell Research, 11(6), 355–361. 8. Bisset el al, 2003. 9. Pelletier-Louis, M.-L. (2017). Peelings chimiques et prise en charge du vieillissement cutané. Annales de Chirurgie Plastique Esthétique, 62(5), 520–531. doi:10.1016/j.anplas.2017.07.001 10. Unit of Biotechnology. Study in vitro on melanin synthesis by spectrophotometry mesoestetic Pharma Group, SL. 2019. 11. Unit of Biotechnology. Study in vitro of the IL-6 marker by ELISA in culture of melanocytes mesoestetic Pharma Group, S.L. 2019; 3. Test on skin release with active ingredient using the RP-HPLC technique. 12. Unit of Biotechnology. Study in vitro of the efficacy of Glycyrrhiza Glabra root Extract in the inhibition of melanin. mesoestetic Pharma Group, S.L. 2019. 13. Unit of Biotechnology. Study in vitro of the efficacy of niacinamide in the prevention of transfer to keratinocytes. mesoestetic Pharma Group, S.L. 2019. 14. Unit of Biotechnology. Study in vitro of the efficacy of Plankton extract in the inhibition of melanin. mesoestetic Pharma Group, S.L. 2019. 15. Study in vivo of the efficacy of niacinamide in the prevention of transepidermal water loss TEWL. mesoestetic Pharma Group, S.L. 2019. 16. A multicentre, efficacy and safety clinical study of a new method (dermamelan® intimate) consisting of a 2-stage protocol: one session at the clinic and a treatment for home use